See all 4163 hotels in Rancho Santa Margarita
- Sonesta Irvine John Wayne Airport
- Sonesta Select Laguna Hills Irvine Spectrum
- ALO Hotel by Ayres
- Laguna Hills Lodge
- La Quinta Inn & Suites by Wyndham Orange County Airport
- Hyatt Regency Irvine
- Embassy Suites by Hilton Irvine Orange County Airport
- Embassy Suites by Hilton Santa Ana Orange County Airport
- Atrium Hotel at Orange County Airport
- Ayres Hotel Orange
- Hyatt Regency Newport Beach West
- Best Western Corona Hotel & Suites
- Laguna Beach House
- Sonesta Anaheim Resort Area
- Casablanca Inn
- Motel 6 Irvine - Orange County Airport
- Ayres Hotel Laguna Woods - Aliso Viejo
- Hilton Garden Inn Irvine Spectrum Lake Forest
- The Westin South Coast Plaza, Costa Mesa
- Homewood Suites By Hilton Irvine John Wayne Airport
- Laguna Cliffs Marriott Resort and Spa
- Extended Stay America Suites Orange County Irvine Spectrum
- Casa Loma Beach Hotel (formerly The Inn at Laguna Beach)
- Hilton Orange County/Costa Mesa
- Ayres Hotel & Spa Mission Viejo – Lake Forest