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Independent in Cairo

Quality Inn Cairo I-57

13201 Kessler Road, Cairo, IL

$64

includes taxes & fees

$58 per night

Dec 7 - Dec 8

Free Cancellation

Reserve now, pay when you stay

2.7 mi from city center

With a stay at Quality Inn Cairo I-57 in Cairo, you'll be within a 15-minute drive of Mississippi River and Ohio River.

Pool

Breakfast included

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St, Charleston, MO

$65

includes taxes & fees

$59 per night

Nov 17 - Nov 18

Free Cancellation

Reserve now, pay when you stay

10.04 mi from city center

A stay at Super 8 by Wyndham Charleston/Sikeston East MO places you in the heart of Charleston, and within a 15-minute drive of The Book Bug.

Breakfast included

Pet friendly

Quality Inn Charleston - Sikeston

102 Drake St, I-57 Exit 10, Charleston, MO

$67

includes taxes & fees

$61 per night

Dec 1 - Dec 2

Free Cancellation

Reserve now, pay when you stay

11.71 mi from city center

Located in Charleston, Quality Inn Charleston - Sikeston is within a 15-minute drive of The Book Bug and City of Miner Convention Center.

Breakfast included

Pet friendly

Charming cottage overlooking Lake Acre

$285

includes taxes & fees

$285 per night

Nov 11 - Nov 12

24.79 mi from city center

Located in Dongola, this cabin is on a lake, within a 15-minute drive of Dongola Lake and Dongola Public Library.

Kitchen

Washer

Cozy cabins on beautiful Horseshoe Lake

$145

includes taxes & fees

$145 per night

Nov 11 - Nov 12

14.88 mi from city center

This cabin is 0.4 mi (0.7 km) from Shawnee National Forest and 5.2 mi (8.4 km) from Mississippi River.

Air conditioning

Lake view

Beautiful Cabin Retreat

$194

includes taxes & fees

$194 per night

Nov 20 - Nov 21

21.95 mi from city center

With a stay at this vacation home in Tamms, you'll be within a 15-minute drive of Shawnee National Forest and Ullin City Hall.

Pet friendly

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

17.75 mi from city center

With a stay at this vacation home in Kevil, you'll be 16.8 mi (27.1 km) from Mississippi River and 27 mi (43.4 km) from Shawnee National Forest.

Breakfast included

Kitchen

The Rested Duck Mallard Room

$154

includes taxes & fees

$145 per night

Nov 15 - Nov 16

14.88 mi from city center

This cabin is 0.4 mi (0.7 km) from Shawnee National Forest and 5.2 mi (8.4 km) from Mississippi River.

Air conditioning

Upscale & Quiet Paducah Retreat on 15 Acres!

20.46 mi from city center

With a stay at this cabin in West Paducah, you'll be within a 15-minute drive of West Kentucky Community and Technical College and Whitehaven Welcome Center.

Charming Home just minutes from Interstate and Mall

$188

includes taxes & fees

$166 per night

Dec 3 - Dec 4

18.71 mi from city center

When you stay at this vacation home in Kevil, you'll be 13 minutes by car from Kentucky Oaks Mall.

Kitchen

Washer

Eagle Inn Charleston

2811 East Marshall Street, Charleston, MO

$77

includes taxes & fees

$69 per night

Nov 11 - Nov 12

Free Cancellation

Reserve now, pay when you stay

9.28 mi from city center

With a stay at Eagle Inn Charleston in Charleston, you'll be 10.1 mi (16.3 km) from Mississippi River and 20.6 mi (33.1 km) from Shawnee National Forest.

La Center Motel

474 W Kentucky Dr, La Center, KY

Free Cancellation

Reserve now, pay when you stay

11.79 mi from city center

With a stay at La Center Motel in La Center, you'll be 11.1 mi (17.9 km) from Mississippi River and 29.6 mi (47.6 km) from Shawnee National Forest.

Parking included

Free WiFi

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Cairo hotels essential information

Accommodation	26 hotels
Lowest Price	$64
Highest Price	$285
Popular hotels	Quality Inn Cairo I-57, Super 8 by Wyndham Charleston/Sikeston East MO, Quality Inn Charleston - Sikeston, Charming cottage overlooking Lake Acre, Cozy cabins on beautiful Horseshoe Lake, Beautiful Cabin Retreat, Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286, The Rested Duck Mallard Room, Upscale & Quiet Paducah Retreat on 15 Acres!, Charming Home just minutes from Interstate and Mall, Eagle Inn Charleston, La Center Motel

Most Recent Cairo Hotel Reviews

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

5 out of 5

Posted 6 days ago

CheapTickets Verified Review

"Peace and quiet abound at this place. Lots of room outside to enjoy and charm inside. Mattress was very comfortable sleeping and kitchen well stocked for cooking, something we wanted to do. Nice that breakfast options provided. "

A verified traveler stayed at Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286