Compare Hotels on the Lake in Seneca

Secret Bargains - Save an extra 10% or more on select Hotels on the Lake

Get more for your budget and save up to 50% off select Secret Bargain hotels

Get even more value with CheapTickets Price Guarantee!

Change your flight without a fee on select flights

Featured Seneca Hotels on the Lake

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Located in Seneca, this vacation home is on the waterfront, within a 15-minute drive of Lake Hartwell and Friendship Recreaction Area.
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
The price is $133 per night
$133
includes taxes & fees
$121 per night
Dec 5 - Dec 6
Free Cancellation
Reserve now, pay when you stay
When you stay at Hampton Inn & Suites Seneca-Clemson Area in Seneca, you'll be in the business district, a 2-minute drive from Lake Keowee and 7 minutes from Clemson University.
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
The price is $108 per night
$108
includes taxes & fees
$98 per night
Nov 12 - Nov 13
Free Cancellation
Reserve now, pay when you stay
With a stay at Best Western Seneca-Clemson in Seneca, you'll be a 1-minute drive from Lake Keowee and 8 minutes from Clemson University.
Pool
Breakfast included
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd, Seneca, SC
The price is $77 per night
$77
includes taxes & fees
$70 per night
Dec 2 - Dec 3
Free Cancellation
Reserve now, pay when you stay
When you stay at Days Inn by Wyndham Seneca / Clemson Area in Seneca, you'll be in the business district, within a 15-minute drive of Lake Keowee and Clemson University.
Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

With a stay at this cabin in Seneca, you'll be within a 15-minute drive of Lake Keowee and Golden Corner Plaza.
Don't see what you're looking for?
See all available properties in Seneca
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Often, one of the most difficult things about booking a hotel is finding the best time to go. The cost of staying in hotels in could vary significantly, depending on the time of the year chosen. If you would like to figure out the most suitable time to take a trip then using CheapTickets could be the best option for you. We will be able to provide information on hotels in to ensure that you get the best deal possible. So if you are looking for a booking website that will streamline the process and offer good prices, then log in and get booking.

Seneca hotels essential information

Accommodation
1,522 hotels
Lowest Price
$77
Highest Price
$133
Popular hotels
 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks, Hampton Inn & Suites Seneca-Clemson Area, Best Western Seneca-Clemson, Days Inn by Wyndham Seneca / Clemson Area, Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Most Recent Seneca Hotel Reviews

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

5 out of 5
Posted 1 day ago
CheapTickets Verified Review
"The Shepherd is my location of choice from now on when I travel to Clemson. Everything was outstanding and I must say that the staff was one of the friendliest that I have ever experienced. Going to Clemson? Stay at the Shepherd! "
A verified traveler from Orlando stayed at The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson

Types of Hotels

Top 20 Seneca Hotels

Hotels Near Seneca

Top Hotel Brands

Hotels By Star Rating

Cities near Seneca

More Ways to Book