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Featured Seneca Hotels with Air Conditioning

Best Western Seneca-Clemson

511 Bypass Highway 123, Seneca, SC

Free Cancellation

Reserve now, pay when you stay

With a stay at Best Western Seneca-Clemson in Seneca, you'll be within a 10-minute drive of Clemson University and Lake Keowee.

Pool

Breakfast included

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Located in Seneca, this cabin is within a 15-minute drive of Lake Keowee and Golden Corner Plaza.

Kitchen

Washer

Days Inn by Wyndham Seneca / Clemson Area

11015 N Radio Station Rd, Seneca, SC

$79

includes taxes & fees

$71 per night

Jan 19 - Jan 20, 2025

Free Cancellation

Reserve now, pay when you stay

With a stay at Days Inn by Wyndham Seneca / Clemson Area in Seneca, you'll be in the business district, within a 15-minute drive of Clemson University and Applewood Shopping Center.

Pool

Breakfast included

Hampton Inn & Suites Seneca-Clemson Area

1011 East North 1st Street, Seneca, SC

Free Cancellation

Reserve now, pay when you stay

With a stay at Hampton Inn & Suites Seneca-Clemson Area in Seneca, you'll be in the business district, within a 10-minute drive of Clemson University and Wyndham Plaza.

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Located in Seneca, this vacation home is on the waterfront, within a 15-minute drive of Lake Hartwell and Friendship Recreaction Area.

Quality Inn Seneca US-123

226 Hi Tech Rd, Seneca, SC

Free Cancellation

Reserve now, pay when you stay

With a stay at Quality Inn Seneca US-123, you'll be centrally located in Seneca, within a 15-minute drive of Clemson University and The Gauntlet.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Seneca hotels essential information

Accommodation	1,499 hotels
Lowest Price	$79
Highest Price	$79
Popular hotels	Best Western Seneca-Clemson, Fall fun at the cabin! Convenient to Lake Keowee and Clemson, Days Inn by Wyndham Seneca / Clemson Area, Hampton Inn & Suites Seneca-Clemson Area, 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks, Quality Inn Seneca US-123