Compare Cheap Hotels in Isle of Palms Florida

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 3-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center.

When you stay at Margaritaville Jacksonville Beach in Jacksonville Beach, you'll be on the beach, within a 15-minute drive of Mayo Clinic Florida and Mayport Naval Station.

Hyatt Regency Jacksonville is centrally located in Jacksonville, a 4-minute walk from Florida Theatre and 11 minutes by foot from Times-Union Center for the Performing Arts.

With a stay at Hyatt Place Jacksonville Airport in Jacksonville (Northside), you'll be within a 10-minute drive of Jacksonville Zoo and Gardens and UF Health North.

With a stay at The Villas of Amelia Island in Fernandina Beach, you'll be 1.3 mi (2 km) from Fort George Island Cultural State Park and 10 mi (16 km) from Fort Clinch State Park.

Located in Jacksonville (Southside), Wyndham Garden Jacksonville is within a 10-minute drive of St. Johns Town Center and University of North Florida.

A stay at Southbank Hotel by Marriott Jacksonville Riverwalk places you in the heart of Jacksonville, within a 5-minute drive of Baptist Medical Center Jacksonville and VyStar Veterans Memorial Arena.

With a stay at Extended Stay America Premier Suites - Jacksonville - Airport in Jacksonville (Northside), you'll be within a 10-minute drive of Jacksonville Zoo and Gardens and UF Health Hospital North.

Located in Jacksonville (Southside), Candlewood Suites Jacksonville Southpoint by IHG is within a 10-minute drive of St. Johns Town Center and The Avenues.

A stay at DoubleTree by Hilton Hotel Jacksonville Riverfront places you in the heart of Jacksonville, within a 5-minute drive of Jacksonville Museum of Modern Art and VyStar Veterans Memorial Arena.

When you stay at Hampton Inn Jacksonville Beach/Oceanfront in Jacksonville Beach, you'll be on the beach, within a 15-minute drive of Mayo Clinic Florida and Mayport Naval Station.

With a stay at Omni Amelia Island Resort & Spa in Fernandina Beach, you'll be 2.9 mi (4.7 km) from Fort George Island Cultural State Park and 8.9 mi (14.3 km) from Fort Clinch State Park.