See all 2628 hotels in South Carolina Midlands
- Hilton Garden Inn Columbia/Harbison
- Marriott Columbia
- Quality Inn Columbia Airport
- Baymont by Wyndham Columbia Northwest
- Delta Hotels by Marriott Columbia Northeast
- MainStay Suites Columbia Harbison
- Days Inn by Wyndham Florence Near Civic Center
- Doubletree by Hilton Columbia, SC
- La Quinta Inn & Suites by Wyndham Florence
- Quality Inn & Suites Ft. Jackson Maingate
- Hampton Inn & Suites Florence Center