Compare Cheap Hotels in South Central Houston Texas
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Cheap South Central Houston Hotels
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
$322 nightly
The price is $377 total per night
$377 total
Dec 16 - Dec 17
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.69 mi from South Central Houston
With a stay at Hotel Zaza Houston Museum District, you'll be centrally located in Houston, within a 5-minute drive of Rice University and MD Anderson Cancer Center.
Pool
Pet friendly
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
$89 nightly
The price is $105 total per night
$105 total
Dec 22 - Dec 23
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
2.72 mi from South Central Houston
With a stay at Hilton Houston Plaza/Medical Center, you'll be centrally located in Houston, within a 5-minute drive of MD Anderson Cancer Center and Rice University.
Downtowner Inns - Houston Downtown
2510 Hamilton St Houston TX
$86 nightly
The price is $100 total per night
$100 total
Dec 16 - Dec 17
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
0.95 mi from South Central Houston
With a stay at Downtowner Inns - Houston Downtown in Houston (Houston Central Business District), you'll be within a 5-minute drive of George R. Brown Convention Center and Toyota Center.
InterContinental Houston by IHG
6750 Main St Houston TX
$164 nightly
The price is $192 total per night
$192 total
Dec 18 - Dec 19
Total with taxes and fees
Free Cancellation
2.89 mi from South Central Houston
With a stay at InterContinental Houston by IHG, you'll be centrally located in Houston, a 8-minute walk from Texas Children's Hospital and 12 minutes by foot from MD Anderson Cancer Center.
The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
$173 nightly
The price is $201 total per night
$201 total
Dec 18 - Dec 19
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
2.64 mi from South Central Houston
With a stay at The Westin Houston Medical Center/Museum District in Houston (Texas Medical Center), you'll be within a 5-minute drive of Houston Zoo and Hermann Park.
DoubleTree by Hilton Houston Medical Center Hotel & Suites
6800 Main Street Houston TX
$88 nightly
The price is $103 total per night
$103 total
Jan 15 - Jan 16, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
2.91 mi from South Central Houston
With a stay at DoubleTree by Hilton Houston Medical Center Hotel & Suites, you'll be centrally located in Houston, a 7-minute walk from Texas Children's Hospital and 12 minutes by foot from MD Anderson Cancer Center.
Houston Marriott Medical Center/Museum District
6580 Fannin Street Houston TX
$170 nightly
The price is $199 total per night
$199 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
2.61 mi from South Central Houston
With a stay at Houston Marriott Medical Center/Museum District in Houston (Texas Medical Center), you'll be steps from Houston Methodist Hospital and 3 minutes by foot from Texas Children's Hospital.
Wanderstay Boutique Hotel
520 Sampson St Houston TX
$113 nightly
The price is $132 total per night
$132 total
Dec 16 - Dec 17
Total with taxes and fees
Free Cancellation
1.85 mi from South Central Houston
Located in Houston (South Central Houston), Wanderstay Boutique Hotel is within a 5-minute drive of Shell Energy Stadium and Daikin Park.
Hilton University of Houston
4450 University Drive Houston TX
$147 nightly
The price is $172 total per night
$172 total
Dec 21 - Dec 22
Total with taxes and fees
1.42 mi from South Central Houston
With a stay at Hilton University of Houston in Houston (Southeast Houston), you'll be a 2-minute drive from University of Houston and 6 minutes from Toyota Center.
Mint House Houston – Medical Center
1911 Holcombe Boulevard Houston TX
2.18 mi from South Central Houston
With a stay at Mint House Houston – Medical Center in Houston (Texas Medical Center), you'll be within a 5-minute drive of Houston Zoo and MD Anderson Cancer Center.
Americas Best Value Inn Medical Center Downtown
2419 Riverside Dr Houston TX
$83 nightly
The price is $97 total per night
$97 total
Dec 16 - Dec 17
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
1.18 mi from South Central Houston
A stay at Americas Best Value Inn Medical Center Downtown places you in the heart of Houston, within a 5-minute drive of Children's Museum of Houston and Houston Natural Science Museum.
Extended Stay America Suites Houston Med Ctr Braeswood Bl
1301 Braeswood Blvd Houston TX
$80 nightly
The price is $94 total per night
$94 total
Dec 21 - Dec 22
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
2.93 mi from South Central Houston
With a stay at Extended Stay America Suites Houston Med Ctr Braeswood Bl in Houston (Texas Medical Center), you'll be within a 5-minute drive of MD Anderson Cancer Center and Rice University.
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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South Central Houston hotels essential information
Accommodation | 1,171 hotels |
|---|---|
Lowest Price | $94 |
Highest Price | $377 |
Popular hotels | Hotel Zaza Houston Museum District, Hilton Houston Plaza/Medical Center, Downtowner Inns - Houston Downtown, InterContinental Houston by IHG, The Westin Houston Medical Center/Museum District, DoubleTree by Hilton Houston Medical Center Hotel & Suites, Houston Marriott Medical Center/Museum District, Wanderstay Boutique Hotel, Hilton University of Houston, Mint House Houston – Medical Center, Americas Best Value Inn Medical Center Downtown, Extended Stay America Suites Houston Med Ctr Braeswood Bl |
Most Recent South Central Houston Hotel Reviews
The Westin Houston Medical Center/Museum District
5 out of 5
Posted 2 days ago
CheapTickets Verified Review
"Staff are very friendly and attentive. Hotel is clean no maintenance issue noted by any means. Location was easily accessible by uber. Rooms were quiet except for when emergency sirens go off (mind you I was on the ninth floor). Bed and bedding were very superb especially when the weather outside is 50 degrees. Would recommend. "
A verified traveler stayed at The Westin Houston Medical Center/Museum District
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