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Featured Muscatine Business Hotels

Hampton Inn Muscatine

Hampton Inn Muscatine

2.5 out of 5
3303 N Port Drive Muscatine IA
$93 nightly
The price is $105 total per night
$105 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Hampton Inn Muscatine in Muscatine, you'll be within a 10-minute drive of Mississippi River and Muscatine Municipal Golf Course.
Breakfast included
Pet friendly
AmericInn by Wyndham Muscatine

AmericInn by Wyndham Muscatine

2.5 out of 5
3115 Hwy 61 North Muscatine IA
$81 nightly
The price is $90 total per night
$90 total
Dec 25 - Dec 26
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at AmericInn by Wyndham Muscatine in Muscatine, you'll be in a shopping district, within a 10-minute drive of Mississippi River and Muscatine Municipal Golf Course.
Pool
Hot Tub
Comfort Inn Muscatine near Hwy 61

Comfort Inn Muscatine near Hwy 61

2.5 out of 5
115 Cleveland St Muscatine IA
$73 nightly
The price is $81 total per night
$81 total
Jan 16 - Jan 17, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Comfort Inn Muscatine near Hwy 61 in Muscatine, you'll be in a shopping district, within a 5-minute drive of Mississippi River and Muscatine Aquatic Center.
Pool
Breakfast included
Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel

2.5 out of 5
305 Cleveland St Muscatine IA
$90 nightly
The price is $101 total per night
$101 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Free Cancellation
Reserve now, pay when you stay
With a stay at Best Western Muscatine / Pearl City Hotel in Muscatine, you'll be 25.6 mi (41.1 km) from Jumer's Casino & Hotel and 26.6 mi (42.8 km) from Rhythm City Casino.
Pool
Breakfast included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Muscatine hotels essential information

Accommodation
300 hotels
Lowest Price
$81
Highest Price
$105
Popular hotels
Hampton Inn Muscatine, AmericInn by Wyndham Muscatine, Comfort Inn Muscatine near Hwy 61, Best Western Muscatine / Pearl City Hotel

Most Recent Muscatine Hotel Reviews

DoubleTree by Hilton Davenport

DoubleTree by Hilton Davenport

5 out of 5
Posted 4 days ago
CheapTickets Verified Review
"Room was great. Nathan and Tiffani were so so so exceptional!! We thought the fact in our shower was broke but turns out it was just extremely tight to turn. When I contacted them I got nothing but amazing customer service. They made our stay the best. They made us feel like we were very important. Thank you Nathan and Tiffani!!!"
A verified traveler stayed at DoubleTree by Hilton Davenport
DoubleTree by Hilton Davenport

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