Cheap Vacations in Cayo Santa Maria

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3-night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Club De Soleil All-Suite Resort

Club De Soleil All-Suite Resort

3 out of 5
Save 100% on your flight
per person
Jan 31 - Feb 3
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Las Vegas (LAS)
The Westin New York Grand Central

The Westin New York Grand Central

4.5 out of 5
per person
Jan 22 - Jan 25
found 9 hours ago
Roundtrip flight included
Detroit (DTW) to New York (JFK)
The William Vale

The William Vale

5 out of 5
Save 100% on your flight
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to New York (JFK)
Solé Miami, A Noble House Resort

Solé Miami, A Noble House Resort

4 out of 5
Save 100% on your flight
per person
Jan 23 - Jan 26
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
President Villa

President Villa

3.5 out of 5
Save 100% on your flight
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
President Hotel

President Hotel

3.5 out of 5
Save 100% on your flight
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
Save 100% on your flight
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
W South Beach

W South Beach

5 out of 5
Save 100% on your flight
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Henrosa Hotel

Henrosa Hotel

3.5 out of 5
Save 100% on your flight
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Trump International Beach Resort

Trump International Beach Resort

4.5 out of 5
Save 100% on your flight
per person
Jan 23 - Jan 26
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
Pelican Hotel

Pelican Hotel

4 out of 5
Save 100% on your flight
per person
Jan 24 - Jan 27
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
Terranea Resort

Terranea Resort

5 out of 5
Save 100% on your flight
per person
Feb 13 - Feb 16
found 9 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Los Angeles (LAX)

4-night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
The LINQ Hotel + Experience

The LINQ Hotel + Experience

4 out of 5
per person
Feb 11 - Feb 15
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Las Vegas (LAS)
The Westin New York Grand Central

The Westin New York Grand Central

4.5 out of 5
per person
Jan 18 - Jan 22
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to New York (JFK)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
per person
Jan 19 - Jan 23
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Desert Vacation Villas by VRI Americas

Desert Vacation Villas by VRI Americas

3 out of 5
Save 100% on your flight
per person
Feb 2 - Feb 6
found 15 hours ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Los Angeles (LAX)
The Velvet Rope

The Velvet Rope

3 out of 5
Save 100% on your flight
per person
Feb 2 - Feb 6
found 15 hours ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Los Angeles (LAX)
Henrosa Hotel

Henrosa Hotel

3.5 out of 5
Save 100% on your flight
per person
Feb 9 - Feb 13
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Trump International Beach Resort

Trump International Beach Resort

4.5 out of 5
Save 100% on your flight
per person
Feb 3 - Feb 7
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Kimpton EPIC Hotel, an IHG Hotel

Kimpton EPIC Hotel, an IHG Hotel

5 out of 5
Save 100% on your flight
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Costa Hollywood Beach Resort

Costa Hollywood Beach Resort

4 out of 5
Save 100% on your flight
per person
Jan 25 - Jan 29
found 2 days ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
President Villa

President Villa

3.5 out of 5
Save 100% on your flight
per person
Feb 9 - Feb 13
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Solé Miami, A Noble House Resort

Solé Miami, A Noble House Resort

4 out of 5
Save 100% on your flight
per person
Feb 3 - Feb 7
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
SIRTAJ - Beverly Hills

SIRTAJ - Beverly Hills

4 out of 5
Save 100% on your flight
per person
Jan 28 - Feb 1
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Los Angeles (LAX)

5-night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Hollywood Inn Suites Hotel

Hollywood Inn Suites Hotel

2.5 out of 5
per person
Jan 30 - Feb 4
found 24 hours ago
Roundtrip flight included
Portland (PDX) to Los Angeles (LAX)
SIRTAJ - Beverly Hills

SIRTAJ - Beverly Hills

4 out of 5
Save 100% on your flight
per person
Jan 23 - Jan 28
found 12 hours ago
Roundtrip flight included
Philadelphia (PHL) to Los Angeles (LAX)
Level Los Angeles Downtown - South Olive

Level Los Angeles Downtown - South Olive

4.5 out of 5
Save 100% on your flight
per person
Jan 23 - Jan 28
found 12 hours ago
Roundtrip flight included
Philadelphia (PHL) to Los Angeles (LAX)
The Westin New York Grand Central

The Westin New York Grand Central

4.5 out of 5
per person
Jan 20 - Jan 25
found 1 day ago
Roundtrip non-stop flight included
Portland (PDX) to New York (JFK)
Glendale Hotel

Glendale Hotel

2.5 out of 5
per person
Jan 30 - Feb 4
found 24 hours ago
Roundtrip flight included
Portland (PDX) to Los Angeles (LAX)
The Retreat Collection at 1 Hotel & Homes South Beach

The Retreat Collection at 1 Hotel & Homes South Beach

5 out of 5
per person
Jan 28 - Feb 2
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Miami (MIA)
The Velvet Rope

The Velvet Rope

3 out of 5
per person
Jan 31 - Feb 5
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to Los Angeles (LAX)
Planet Hollywood Resort & Casino

Planet Hollywood Resort & Casino

4 out of 5
per person
Jan 20 - Jan 25
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Las Vegas (LAS)
Desert Vacation Villas by VRI Americas

Desert Vacation Villas by VRI Americas

3 out of 5
Save 100% on your flight
per person
Jan 31 - Feb 5
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to Los Angeles (LAX)
The Orleans Hotel & Casino

The Orleans Hotel & Casino

3.5 out of 5
Save 100% on your flight
per person
Jan 20 - Jan 25
found 15 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Las Vegas (LAS)
Mayfair House Hotel & Garden

Mayfair House Hotel & Garden

4.5 out of 5
Save 100% on your flight
per person
Feb 9 - Feb 14
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Miami (MIA)
Hotel Erwin Venice Beach

Hotel Erwin Venice Beach

4 out of 5
Save 100% on your flight
per person
Jan 30 - Feb 4
found 24 hours ago
Roundtrip flight included
Portland (PDX) to Los Angeles (LAX)

6-7 night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Casablanca Inn

Casablanca Inn

2.5 out of 5
Save 100% on your flight
per person
Jan 17 - Jan 24
found 12 hours ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Los Angeles (LAX)
Planet Hollywood Resort & Casino

Planet Hollywood Resort & Casino

4 out of 5
per person
Jan 19 - Jan 26
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Las Vegas (LAS)
Westgate Las Vegas Resort & Casino

Westgate Las Vegas Resort & Casino

4 out of 5
per person
Feb 1 - Feb 7
found 1 hour ago
Roundtrip non-stop flight included
Detroit (DTW) to Las Vegas (LAS)
SIRTAJ - Beverly Hills

SIRTAJ - Beverly Hills

4 out of 5
per person
Feb 3 - Feb 9
found 4 hours ago
Roundtrip flight included
Detroit (DTW) to Los Angeles (LAX)
Element Miami International Airport

Element Miami International Airport

3 out of 5
per person
Feb 7 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
Flow Miami

Flow Miami

2 out of 5
Save 100% on your flight
per person
Feb 7 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
Cavalier Hotel South Beach

Cavalier Hotel South Beach

3.5 out of 5
Save 100% on your flight
per person
Feb 7 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
Glendale Hotel

Glendale Hotel

2.5 out of 5
Save 100% on your flight
per person
Feb 8 - Feb 15
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Los Angeles (LAX)
Carillon Miami Wellness Resort

Carillon Miami Wellness Resort

5 out of 5
per person
Feb 7 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Miami (MIA)
Henrosa Hotel

Henrosa Hotel

3.5 out of 5
Save 100% on your flight
per person
Jan 19 - Jan 26
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Miami (MIA)
The Retreat Collection at 1 Hotel & Homes South Beach

The Retreat Collection at 1 Hotel & Homes South Beach

5 out of 5
per person
Jan 19 - Jan 25
found 5 hours ago
Roundtrip non-stop flight included
Minneapolis (MSP) to Miami (MIA)
Horseshoe Las Vegas

Horseshoe Las Vegas

4 out of 5
Save 100% on your flight
per person
Jan 19 - Jan 26
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Las Vegas (LAS)

Top rated hotels for your Cayo Santa Maria vacation

Villa Gaviota Cayo Coco

Villa Gaviota Cayo Coco

2 out of 5
Ciego de Avila, Cayo Santa Maria
0.21 mi from city center
Get rates
When you stay at Villa Gaviota Cayo Coco in Cayo Santa Maria, you'll be 5.8 mi (9.3 km) from Playa Las Gaviotas.
Grand Memories Santa Maria - All Inclusive

Grand Memories Santa Maria - All Inclusive

3.5 out of 5
Municipio Caibarien, Cayo Santa Maria, Villa Clara
1.39 mi from city center
Get rates
With a stay at Grand Memories Santa Maria - All Inclusive in Cayo Santa Maria, you'll be on the beach, and 4.3 mi (6.9 km) from Playa Las Gaviotas.
Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive

Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive

3.5 out of 5
Cayo Santa Maria, Cayo Santa Maria, Villa Clara
1.55 mi from city center
Get rates
With a stay at Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive in Cayo Santa Maria, you'll be on the beach, and 4.3 mi (7 km) from Playa Las Gaviotas.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

^Savings based on all package bookings with Flight + Hotel made on CheapTickets.com from 2019-04-01 - 2020-03-31 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.