Cheap Vacations in Cayo Santa Maria

Choose two or more items and save on your trip:

3-night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Casa Boutique Hotel

Casa Boutique Hotel

3 out of 5
Save 100% on your flight
per person
Jan 6 - Jan 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
The William Vale

The William Vale

5 out of 5
Save 100% on your flight
per person
Dec 24 - Dec 27
found 20 hours ago
Roundtrip flight included
Chicago (ORD) to New York (JFK)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
per person
Jan 6 - Jan 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Park Royal Miami Beach

Park Royal Miami Beach

2.5 out of 5
Save 100% on your flight
per person
Jan 6 - Jan 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Banana Bay Resort & Marina

Banana Bay Resort & Marina

3 out of 5
Save 100% on your flight
per person
Dec 24 - Dec 27
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to Miami (MIA)
President Villa

President Villa

3.5 out of 5
Save 100% on your flight
per person
Dec 26 - Dec 29
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
May-Dee Suites

May-Dee Suites

2.5 out of 5
Save 100% on your flight
per person
Jan 11 - Jan 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Planet Hollywood Resort & Casino

Planet Hollywood Resort & Casino

4 out of 5
Save 100% on your flight
per person
Dec 30 - Jan 2
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Las Vegas (LAS)
Treasure Island – TI Las Vegas Hotel Casino, a Radisson Hotel

Treasure Island – TI Las Vegas Hotel Casino, a Radisson Hotel

4 out of 5
per person
Dec 30 - Jan 2
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Las Vegas (LAS)
INNSiDE by Meliá New York Nomad

INNSiDE by Meliá New York Nomad

4.5 out of 5
Save 100% on your flight
per person
Dec 17 - Dec 20
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to New York (JFK)
1 Hotel Brooklyn Bridge

1 Hotel Brooklyn Bridge

5 out of 5
Save 100% on your flight
per person
Dec 19 - Dec 22
found 5 hours ago
Roundtrip flight included
Chicago (ORD) to New York (JFK)
Marenas Beach Resort

Marenas Beach Resort

4 out of 5
Save 100% on your flight
per person
Jan 6 - Jan 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)

4-night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Gold Coast Hotel and Casino

Gold Coast Hotel and Casino

3 out of 5
Save 100% on your flight
per person
Jan 6 - Jan 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Las Vegas (LAS)
Westgate Flamingo Bay Resort

Westgate Flamingo Bay Resort

4 out of 5
per person
Jan 6 - Jan 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Las Vegas (LAS)
B Ocean Resort Fort Lauderdale Beach

B Ocean Resort Fort Lauderdale Beach

4 out of 5
Save 100% on your flight
per person
Jan 12 - Jan 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
per person
Jan 2 - Jan 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
The William Vale

The William Vale

5 out of 5
Save 100% on your flight
per person
Dec 19 - Dec 23
found 1 day ago
Roundtrip flight included
Chicago (ORD) to New York (JFK)
Solé Miami, A Noble House Resort

Solé Miami, A Noble House Resort

4 out of 5
Save 100% on your flight
per person
Jan 2 - Jan 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
MGM Vegas Signature Suites Collection

MGM Vegas Signature Suites Collection

4 out of 5
per person
Jan 6 - Jan 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Las Vegas (LAS)
President Hotel

President Hotel

3.5 out of 5
Save 100% on your flight
per person
Jan 2 - Jan 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Desert Vacation Villas by VRI Americas

Desert Vacation Villas by VRI Americas

3 out of 5
Save 100% on your flight
per person
Jan 9 - Jan 13
found 10 hours ago
Roundtrip flight included
Minneapolis (MSP) to Los Angeles (LAX)
May-Dee Suites

May-Dee Suites

2.5 out of 5
Save 100% on your flight
per person
Jan 2 - Jan 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Life Hotel New York

Life Hotel New York

3.5 out of 5
Save 100% on your flight
per person
Dec 26 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to New York (JFK)
Henrosa Hotel

Henrosa Hotel

3.5 out of 5
Save 100% on your flight
per person
Dec 27 - Dec 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)

5-night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Solé Miami, A Noble House Resort

Solé Miami, A Noble House Resort

4 out of 5
Save 100% on your flight
per person
Dec 17 - Dec 22
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
The William Vale

The William Vale

5 out of 5
per person
Dec 21 - Dec 26
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to New York (JFK)
Cavalier Hotel South Beach

Cavalier Hotel South Beach

3.5 out of 5
Save 100% on your flight
per person
Dec 25 - Dec 30
found 13 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Heart of New York Suites

Heart of New York Suites

2 out of 5
per person
Dec 23 - Dec 28
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to New York (JFK)
Henrosa Hotel

Henrosa Hotel

3.5 out of 5
Save 100% on your flight
per person
Dec 26 - Dec 31
found 5 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
per person
Dec 17 - Dec 22
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Life Hotel New York

Life Hotel New York

3.5 out of 5
Save 100% on your flight
per person
Dec 23 - Dec 28
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to New York (JFK)
Westgate Flamingo Bay Resort

Westgate Flamingo Bay Resort

4 out of 5
Save 100% on your flight
per person
Jan 9 - Jan 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Las Vegas (LAS)
Bentley Hotel South Beach

Bentley Hotel South Beach

4 out of 5
per person
Jan 1 - Jan 6
found 20 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Fairmont Century Plaza

Fairmont Century Plaza

5 out of 5
Save 100% on your flight
per person
Jan 1 - Jan 6
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Los Angeles (LAX)
Banana Bay Resort & Marina

Banana Bay Resort & Marina

3 out of 5
Save 100% on your flight
per person
Jan 5 - Jan 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Miami (MIA)
NobleDEN Hotel

NobleDEN Hotel

4 out of 5
Save 100% on your flight
per person
Dec 23 - Dec 28
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to New York (JFK)

6-7 night Cayo Santa Maria vacations

Price found within the past 48 hours. Click for updated prices.
Broadmore Miami Beach

Broadmore Miami Beach

3.5 out of 5
Save 100% on your flight
per person
Jan 8 - Jan 14
found 16 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
per person
Dec 27 - Jan 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
EAST Miami

EAST Miami

5 out of 5
per person
Jan 9 - Jan 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Cavalier Hotel South Beach

Cavalier Hotel South Beach

3.5 out of 5
per person
Dec 27 - Jan 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Heart of New York Suites

Heart of New York Suites

2 out of 5
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to New York (JFK)
President Hotel

President Hotel

3.5 out of 5
Save 100% on your flight
per person
Dec 27 - Jan 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Casa Boutique Hotel

Casa Boutique Hotel

3 out of 5
Save 100% on your flight
per person
Dec 27 - Jan 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Life Hotel New York

Life Hotel New York

3.5 out of 5
Save 100% on your flight
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to New York (JFK)
NobleDEN Hotel

NobleDEN Hotel

4 out of 5
Save 100% on your flight
per person
Dec 20 - Dec 26
found 1 day ago
Roundtrip non-stop flight included
Minneapolis (MSP) to New York (JFK)
Bentley Hotel South Beach

Bentley Hotel South Beach

4 out of 5
per person
Dec 28 - Jan 4
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)
Seacoast Suites on Miami Beach

Seacoast Suites on Miami Beach

3.5 out of 5
Save 100% on your flight
per person
Dec 19 - Dec 26
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to Miami (MIA)
Carillon Miami Wellness Resort

Carillon Miami Wellness Resort

5 out of 5
Save 100% on your flight
per person
Jan 9 - Jan 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Miami (MIA)

Top rated hotels for your Cayo Santa Maria vacation

Villa Gaviota Cayo Coco

Villa Gaviota Cayo Coco

2 out of 5
Ciego de Avila, Cayo Santa Maria
0.21 mi from city center
Get rates
When you stay at Villa Gaviota Cayo Coco in Cayo Santa Maria, you'll be 5.8 mi (9.3 km) from Playa Las Gaviotas.
Grand Memories Santa Maria - All Inclusive

Grand Memories Santa Maria - All Inclusive

3.5 out of 5
Municipio Caibarien, Cayo Santa Maria, Villa Clara
1.39 mi from city center
Get rates
With a stay at Grand Memories Santa Maria - All Inclusive in Cayo Santa Maria, you'll be on the beach, and 4.3 mi (6.9 km) from Playa Las Gaviotas.
Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive

Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive

3.5 out of 5
Cayo Santa Maria, Cayo Santa Maria, Villa Clara
1.55 mi from city center
Get rates
With a stay at Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive in Cayo Santa Maria, you'll be on the beach, and 4.3 mi (7 km) from Playa Las Gaviotas.
Don't see what you're looking for?
See all available properties in Cayo Santa Maria
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

^Savings based on all package bookings with Flight + Hotel made on CheapTickets.com from 2019-04-01 - 2020-03-31 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.