See all 353 hotels in Panhandle
- Country Inn & Suites by Radisson, Amarillo I-40 West, TX
- Atrea Inn Amarillo
- Baymont by Wyndham Amarillo East
- Studio 6 Amarillo, TX – West Medical Center
- Four Points by Sheraton Amarillo Central
- Days Inn by Wyndham Amarillo East
- Sleep Inn & Suites West Medical Center
- Hampton Inn & Suites Amarillo East
- Route 66 Inn
- The Relic is located behind a 1920s home in a historic district of Amarillo.