See all 807 hotels in Depew
- Buffalo Airport Hotel
- Holiday Inn Express Grand Island - Niagara Falls, an IHG Hotel
- Garden Place Hotel
- La Quinta Inn & Suites by Wyndham Buffalo Amherst
- Fairbridge Inn Express Buffalo Airport Williamsville
- Red Roof Inn Buffalo - Niagara Airport
- The Delavan Hotel & Spa
- Hampton Inn Buffalo-Airport / Galleria Mall
- DoubleTree by Hilton Hotel Buffalo - Amherst
- Holiday Inn Express & Suites Buffalo Downtown - Medical CTR, an IHG Hotel
- Buffalo Marriott Niagara
- The Westin Buffalo
- Red Roof Inn PLUS+ University at Buffalo - Amherst